Rat Dut cDNA Clone(NM_001040271.1)

Name: Rat Dut cDNA Clone(NM_001040271.1)
SKU: CDFR004742
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR004742

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Product Information

Gene Information

Cat. No.	CDFR004742
Description	NativeORF clone of Rattus norvegicus deoxyuridine triphosphatase (Dut), nuclear gene encoding mitochondrial protein, transcript variant 2 as transfection-ready DNA NM_001040271.1
Product Type	cDAN Clone
Gene Abbr	Dut
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

DUT

Background

This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]

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