Rat Dlat cDNA Clone(NM_031025.1)

Name: Rat Dlat cDNA Clone(NM_031025.1)
SKU: CDFR012501
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR012501

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Product Information

Gene Information

Cat. No.	CDFR012501
Description	NativeORF clone of Rattus norvegicus dihydrolipoamide S-acetyltransferase (Dlat) as transfection-ready DNA NM_031025.1
Product Type	cDAN Clone
Gene Abbr	Dlat
Species	Rat
Vector	pCMV6Entry

Target Gene

DLAT

Background

This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.[provided by RefSeq, Oct 2009]

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