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Rat Dkc1 cDNA Clone(NM_133419.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR014018

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Gene Information

Cat. No. CDFR014018
Description NativeORF clone of Rattus norvegicus dyskeratosis congenita 1, dyskerin (Dkc1) as transfection-ready DNA NM_133419.1
Product Type cDAN Clone
Gene Abbr Dkc1
Species Rat
Vector pCMV6Entry
Target Gene DKC1
Background This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
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