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Rat Dcc ORF Clone(NM_012841.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR377700

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Product Information

Gene Information

Cat. No. CDCR377700
Product Type ORF Clone
Gene Abbr Dcc
Species Rat
Tag C-terminal Myc-DDK
ORF Size 4338 bp
Vector pCMV6-Entry
Target Gene DCC
Background This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]
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