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Rat Dbt cDNA Clone(NM_053312.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR013069

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Gene Information

Cat. No. CDFR013069
Description NativeORF clone of Rattus norvegicus dihydrolipoamide branched chain transacylase E2 (Dbt), nuclear gene encoding mitochondrial protein as transfection-ready DNA NM_053312.1
Product Type cDAN Clone
Gene Abbr Dbt
Species Rat
Vector pCMV6Entry
Target Gene DBT
Background The branched-chain alpha-keto acid dehydrogenase complex (BCKD) is an inner-mitochondrial enzyme complex involved in the breakdown of the branched-chain amino acids isoleucine, leucine, and valine. The BCKD complex is thought to be composed of a core of 24 transacylase (E2) subunits, and associated decarboxylase (E1), dehydrogenase (E3), and regulatory subunits. This gene encodes the transacylase (E2) subunit. Mutations in this gene result in maple syrup urine disease, type 2. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
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