Rat Dazl cDNA Clone(NM_001109414.1)

Name: Rat Dazl cDNA Clone(NM_001109414.1)
SKU: CDFR008807
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR008807

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Product Information

Gene Information

Cat. No.	CDFR008807
Description	NativeORF clone of Rattus norvegicus deleted in azoospermia-like (Dazl) as transfection-ready DNA NM_001109414.1
Product Type	cDAN Clone
Gene Abbr	Dazl
Species	Rat
Vector	pCMV6Entry

Target Gene

DAZL

Background

The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

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