Rat Dap3 cDNA Clone(NM_001011950.2)

Name: Rat Dap3 cDNA Clone(NM_001011950.2)
SKU: CDFR002380
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR002380

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Product Information

Gene Information

Cat. No.	CDFR002380
Description	NativeORF clone of Rattus norvegicus death associated protein 3 (Dap3), nuclear gene encoding mitochondrial protein as transfection-ready DNA NM_001011950.2
Product Type	cDAN Clone
Gene Abbr	Dap3
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

DAP3

Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Dec 2010]

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