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Rat Cyth4 ORF Clone(NM_001130577.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR376807

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Product Information

Gene Information

Cat. No. CDCR376807
Product Type ORF Clone
Gene Abbr Cyth4
Species Rat
Tag C-terminal Myc-DDK
ORF Size 1116 bp
Vector pCMV6-Entry
Target Gene CYTH4
Background This gene encodes a member of the PSCD family of proteins, which have an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family function as GEPs for ADP-ribosylation factors (ARFs), which are guanine nucleotide-binding proteins involved in vesicular trafficking pathways. This protein exhibits GEP activity in vitro with ARF1 and ARF5, but is inactive with ARF6. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
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