Rat Cyp2a3 cDNA Clone(NM_012542.2)

Name: Rat Cyp2a3 cDNA Clone(NM_012542.2)
SKU: CDFR010362
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR010362

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Product Information

Gene Information

Cat. No.	CDFR010362
Description	NativeORF clone of Rattus norvegicus cytochrome P450, family 2, subfamily A, polypeptide 3a (Cyp2a3a) as transfection-ready DNA NM_012542.2
Product Type	cDAN Clone
Gene Abbr	Cyp2a3
Species	Rat
Vector	pCMV6Entry

Target Gene

CYP2A6

Background

This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq, Jul 2008]

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