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Rat Cttn cDNA Clone(NM_021868.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR011801

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Gene Information

Cat. No. CDFR011801
Description NativeORF clone of Rattus norvegicus cortactin (Cttn) as transfection-ready DNA NM_021868.2
Product Type cDAN Clone
Gene Abbr Cttn
Species Rat
Vector pCMV6Entry
Target Gene CTTN
Background This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]
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