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Rat Cse1l cDNA Clone(NM_001108607.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR008200

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Gene Information

Cat. No. CDFR008200
Description NativeORF clone of Rattus norvegicus chromosome segregation 1-like (S. cerevisiae) (Cse1l) as transfection-ready DNA NM_001108607.1
Product Type cDAN Clone
Gene Abbr Cse1l
Species Rat
Vector pCMV6Entry
Target Gene CSE1L
Background Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
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