Rat Crybb3 cDNA Clone(NM_031690.1)

Name: Rat Crybb3 cDNA Clone(NM_031690.1)
SKU: CDFR012826
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR012826

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Product Information

Gene Information

Cat. No.	CDFR012826
Description	NativeORF clone of Rattus norvegicus crystallin, beta B3 (Crybb3) as transfection-ready DNA NM_031690.1
Product Type	cDAN Clone
Gene Abbr	Crybb3
Species	Rat
Vector	pCMV6Entry

Target Gene

CRYBB3

Background

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B2. Mutations in this gene result in cataract congenital nuclear autosomal recessive type 2. [provided by RefSeq, Feb 2013]

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