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Rat Crlf2 cDNA Clone(NM_134465.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR013499

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Gene Information

Cat. No. CDFR013499
Description NativeORF clone of Rattus norvegicus cytokine receptor-like factor 2 (Crlf2) as transfection-ready DNA NM_134465.2
Product Type cDAN Clone
Gene Abbr Crlf2
Species Rat
Vector pCMV6Entry
Target Gene CRLF2
Background This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
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