Rat Coq6 cDNA Clone(NM_001011983.1)

Name: Rat Coq6 cDNA Clone(NM_001011983.1)
SKU: CDFR002412
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR002412

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Product Information

Gene Information

Cat. No.	CDFR002412
Description	NativeORF clone of Rattus norvegicus coenzyme Q6 homolog (yeast) (Coq6) as transfection-ready DNA NM_001011983.1
Product Type	cDAN Clone
Gene Abbr	Coq6
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

COQ6

Background

The protein encoded by this gene belongs to the ubiH/COQ6 family. It is an evolutionarily conserved monooxygenase required for the biosynthesis of coenzyme Q10 (or ubiquinone), which is an essential component of the mitochondrial electron transport chain, and one of the most potent lipophilic antioxidants implicated in the protection of cell damage by reactive oxygen species. Knockdown of this gene in mouse and zebrafish results in decreased growth due to increased apoptosis. Mutations in this gene are associated with autosomal recessive coenzyme Q10 deficiency-6 (COQ10D6), which manifests as nephrotic syndrome with sensorineural deafness. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2012]

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