Rat Col4a1 ORF Clone(NM_001135009.1)

Name: Rat Col4a1 ORF Clone(NM_001135009.1)
SKU: CDCR377099
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR377099

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Product Information

Gene Information

Cat. No.	CDCR377099
Product Type	ORF Clone
Gene Abbr	Col4a1
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	5010 bp
Vector	pCMV6-Entry

Target Gene

COL4A1

Background

This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

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