Rat Ckmt1b cDNA Clone(NM_001012738.1)

Name: Rat Ckmt1b cDNA Clone(NM_001012738.1)
SKU: CDFR002749
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR002749

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Product Information

Gene Information

Cat. No.	CDFR002749
Description	NativeORF clone of Rattus norvegicus creatine kinase, mitochondrial 1, ubiquitous (Ckmt1), nuclear gene encoding mitochondrial protein as transfection-ready DNA NM_001012738.1
Product Type	cDAN Clone
Gene Abbr	Ckmt1b
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

CKMT1B

Background

Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq, Jul 2008]

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