Rat Chrnb3 cDNA Clone(NM_133597.1)

Name: Rat Chrnb3 cDNA Clone(NM_133597.1)
SKU: CDFR014110
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR014110

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Product Information

Gene Information

Cat. No.	CDFR014110
Description	NativeORF clone of Rattus norvegicus cholinergic receptor, nicotinic, beta 3 (Chrnb3) as transfection-ready DNA NM_133597.1
Product Type	cDAN Clone
Gene Abbr	Chrnb3
Species	Rat
Vector	pCMV6Entry2

Target Gene

CHRNB3

Background

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are (hetero)pentamers composed of homologous subunits. The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arranged around the central channel. They are classified as alpha-subunits if, like muscle alpha-1 (MIM 100690), they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteine residues are classified as beta-subunits (Groot Kormelink and Luyten, 1997 [PubMed 9009220]). Elliott et al. (1996) [PubMed 8906617] stated that the proposed structure for each subunit is a conserved N-terminal extracellular domain followed by 3 conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region.[supplied by OMIM, Apr 2010]

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