Rat Cfb cDNA Clone(NM_212466.3)

Name: Rat Cfb cDNA Clone(NM_212466.3)
SKU: CDFR015371
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR015371

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Product Information

Gene Information

Cat. No.	CDFR015371
Description	NativeORF clone of Rattus norvegicus complement factor B (Cfb) as transfection-ready DNA NM_212466.3
Product Type	cDAN Clone
Gene Abbr	Cfb
Species	Rat
Vector	pCMV6Entry

Target Gene

CFB

Background

This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]

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