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Rat Cep290 ORF Clone(NM_001135755.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR377220

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Gene Information

Cat. No. CDCR377220
Product Type ORF Clone
Gene Abbr Cep290
Species Rat
Tag C-terminal Myc-DDK
ORF Size 7440 bp
Vector pCMV6-Entry
Target Gene CEP290
Background This gene encodes a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation. Mutations in this gene have been associated with Joubert syndrome and nephronophthisis and the presence of antibodies against this protein is associated with several forms of cancer. [provided by RefSeq, Jul 2008]
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