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Rat Cebpa ORF Clone(NM_012524.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR377432

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Product Information

Gene Information

Cat. No. CDCR377432
Product Type ORF Clone
Gene Abbr Cebpa
Species Rat
Tag C-terminal Myc-DDK
ORF Size 1077 bp
Vector pCMV6-Entry
Target Gene CEBPA
Background This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]
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