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Rat Cdkn2c ORF Clone(NM_131902.3)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR380980

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Gene Information

Cat. No. CDCR380980
Product Type ORF Clone
Gene Abbr Cdkn2c
Species Rat
Tag C-terminal Myc-DDK
ORF Size 507 bp
Vector pCMV6-Entry
Target Gene CDKN2C
Background The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]
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