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Rat Cdkn1b ORF Clone(NM_031762.3)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR379908

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Product Information

Gene Information

Cat. No. CDCR379908
Product Type ORF Clone
Gene Abbr Cdkn1b
Species Rat
Tag C-terminal Myc-DDK
ORF Size 594 bp
Vector pCMV6-Entry
Target Gene CDKN1B
Background This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]
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