Rat Cd59 cDNA Clone(NM_012925.1)

Name: Rat Cd59 cDNA Clone(NM_012925.1)
SKU: CDFR010766
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR010766

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Product Information

Gene Information

Cat. No.	CDFR010766
Description	NativeORF clone of Rattus norvegicus CD59 molecule, complement regulatory protein (Cd59) as transfection-ready DNA NM_012925.1
Product Type	cDAN Clone
Gene Abbr	Cd59
Species	Rat
Vector	pCMV6Entry

Target Gene

CD59

Background

This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

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