Rat Ccnt1 ORF Clone(NM_001108110.1)

Name: Rat Ccnt1 ORF Clone(NM_001108110.1)
SKU: CDCR374802
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR374802

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Product Information

Gene Information

Cat. No.	CDCR374802
Product Type	ORF Clone
Gene Abbr	Ccnt1
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	1992 bp
Vector	pCMV6-Entry

Target Gene

CCNT1

Background

This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

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