Transfected Stable Cell Lines
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Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
Cat. No. : CDFR009477
| Cat. No. | CDFR009477 |
| Description | NativeORF clone of Rattus norvegicus cerebral cavernous malformation 2 (Ccm2) as transfection-ready DNA NM_001126275.1 |
| Product Type | cDAN Clone |
| Gene Abbr | Ccm2 |
| Species | Rat |
| Vector | pCMV6Entry |
| Target Gene | CCM2 |
| Background | This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009] |
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