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Rat Ccm2 cDNA Clone(NM_001126275.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR009477

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Gene Information

Cat. No. CDFR009477
Description NativeORF clone of Rattus norvegicus cerebral cavernous malformation 2 (Ccm2) as transfection-ready DNA NM_001126275.1
Product Type cDAN Clone
Gene Abbr Ccm2
Species Rat
Vector pCMV6Entry
Target Gene CCM2
Background This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]
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