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Rat Cbs cDNA Clone(NM_012522.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR010199

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Gene Information

Cat. No. CDFR010199
Description NativeORF clone of Rattus norvegicus cystathionine beta synthase (Cbs) as transfection-ready DNA NM_012522.2
Product Type cDAN Clone
Gene Abbr Cbs
Species Rat
Vector pCMV6Entry
Target Gene CBS
Background The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]
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