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Rat Cat ORF Clone(NM_012520.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR377428

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Gene Information

Cat. No. CDCR377428
Product Type ORF Clone
Gene Abbr Cat
Species Rat
Tag C-terminal Myc-DDK
ORF Size 1584 bp
Vector pCMV6-Entry
Target Gene CAT
Background This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
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