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Rat Camlg cDNA Clone(NM_053334.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR013090

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Gene Information

Cat. No. CDFR013090
Description NativeORF clone of Rattus norvegicus calcium modulating ligand (Camlg) as transfection-ready DNA NM_053334.1
Product Type cDAN Clone
Gene Abbr Camlg
Species Rat
Vector pCMV6Entry
Target Gene CAMLG
Background The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]
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