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Rat CDH1 ORF clone(NM_031334.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCL183471

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Product Information

Gene Information

Cat. No. CDCL183471
Description ORF Clone of Rattus norvegicus cadherin 1 DNA.
Product Type ORF clone
Gene Abbr CDH1
Species Rat
ORF Size 2661bp
Vector pGEM-T
Warning This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Storage store at -20°C
Target Gene CDH1
Background This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]
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