Rat CCR3 ORF clone(NM_053958.1)

Name: Rat CCR3 ORF clone(NM_053958.1)
SKU: CDCL183147
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCL183147

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Product Information

Gene Information

Cat. No.	CDCL183147
Description	ORF Clone of Rattus norvegicus chemokine (C-C motif) receptor 3 DNA.
Product Type	ORF clone
Gene Abbr	CCR3
Species	Rat
ORF Size	1080bp
Vector	pGEM-T
Warning	This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Storage	store at -20°C

Target Gene

CCR3

Background

The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]

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