Rat Bcl2a1 cDNA Clone(NM_133416.1)

Name: Rat Bcl2a1 cDNA Clone(NM_133416.1)
SKU: CDFR014015
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR014015

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Product Information

Gene Information

Cat. No.	CDFR014015
Description	NativeORF clone of Rattus norvegicus B-cell leukemia/lymphoma 2 related protein A1d (Bcl2a1d) as transfection-ready DNA NM_133416.1
Product Type	cDAN Clone
Gene Abbr	Bcl2a1
Species	Rat
Vector	pCMV6Entry

Target Gene

BCL2A1

Background

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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