Rat Bcar3 cDNA Clone(NM_001107722.1)

Name: Rat Bcar3 cDNA Clone(NM_001107722.1)
SKU: CDFR007366
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR007366

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Product Information

Gene Information

Cat. No.	CDFR007366
Description	NativeORF clone of Rattus norvegicus breast cancer anti-estrogen resistance 3 (Bcar3) as transfection-ready DNA NM_001107722.1
Product Type	cDAN Clone
Gene Abbr	Bcar3
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

BCAR3

Background

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

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