Rat Bag4 ORF Clone(NM_001025130.1)

Name: Rat Bag4 ORF Clone(NM_001025130.1)
SKU: CDCR370882
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR370882

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Product Information

Gene Information

Cat. No.	CDCR370882
Product Type	ORF Clone
Gene Abbr	Bag4
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	1374 bp
Vector	pCMV6-Entry

Target Gene

BAG4

Background

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

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