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Rat Bag3 cDNA Clone(NM_001011936.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR002367

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Gene Information

Cat. No. CDFR002367
Description NativeORF clone of Rattus norvegicus Bcl2-associated athanogene 3 (Bag3) as transfection-ready DNA NM_001011936.1
Product Type cDAN Clone
Gene Abbr Bag3
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene BAG3
Background BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
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