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Rat Atp6v1b2 cDNA Clone(NM_057213.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR013791

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Gene Information

Cat. No. CDFR013791
Description NativeORF clone of Rattus norvegicus ATPase, H transporting, lysosomal V1 subunit B2 (Atp6v1b2) as transfection-ready DNA NM_057213.2
Product Type cDAN Clone
Gene Abbr Atp6v1b2
Species Rat
Vector pCMV6Entry
Target Gene ATP6V1B2
Background This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq, Jul 2008]
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