Rat Atp6v0e1 cDNA Clone(NM_053578.3)

Name: Rat Atp6v0e1 cDNA Clone(NM_053578.3)
SKU: CDFR013301
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR013301

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Product Information

Gene Information

Cat. No.	CDFR013301
Description	NativeORF clone of Rattus norvegicus ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 (Atp6v0e1) as transfection-ready DNA NM_053578.3
Product Type	cDAN Clone
Gene Abbr	Atp6v0e1
Species	Rat
Vector	pCMV6Entry

Target Gene

ATP6V0E1

Background

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is possibly part of the V0 subunit. Since two nontranscribed pseudogenes have been found in dog, it is possible that the localization to chromosome 2 for this gene by radiation hybrid mapping is representing a pseudogene. Genomic mapping puts the chromosomal location on 5q35.3. [provided by RefSeq, Jul 2008]

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