Rat Atp6v0a4 cDNA Clone(NM_001106591.1)

Name: Rat Atp6v0a4 cDNA Clone(NM_001106591.1)
SKU: CDFR006344
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR006344

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Product Information

Gene Information

Cat. No.	CDFR006344
Description	NativeORF clone of Rattus norvegicus ATPase, H+ transporting, lysosomal V0 subunit A4 (Atp6v0a4) as transfection-ready DNA NM_001106591.1
Product Type	cDAN Clone
Gene Abbr	Atp6v0a4
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

ATP6V0A4

Background

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing. [provided by RefSeq, Jul 2008]

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