Rat Atp6v0a1 cDNA Clone(NM_031604.2)

Name: Rat Atp6v0a1 cDNA Clone(NM_031604.2)
SKU: CDFR012760
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR012760

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Product Information

Gene Information

Cat. No.	CDFR012760
Description	NativeORF clone of Rattus norvegicus ATPase, H+ transporting, lysosomal V0 subunit A1 (Atp6v0a1) as transfection-ready DNA NM_031604.2
Product Type	cDAN Clone
Gene Abbr	Atp6v0a1
Species	Rat
Vector	pCMV6Entry

Target Gene

ATP6V0A1

Background

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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