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Rat Arhgef3 ORF Clone(NM_001106061.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR372863

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Gene Information

Cat. No. CDCR372863
Product Type ORF Clone
Gene Abbr Arhgef3
Species Rat
Tag C-terminal Myc-DDK
ORF Size 1575 bp
Vector pCMV6-Entry
Target Gene ARHGEF3
Background Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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