Rat Alx4 cDNA Clone(NM_001106553.1)

Name: Rat Alx4 cDNA Clone(NM_001106553.1)
SKU: CDFR006258
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR006258

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Product Information

Gene Information

Cat. No.	CDFR006258
Description	NativeORF clone of Rattus norvegicus aristaless-like homeobox 4 (Alx4) as transfection-ready DNA NM_001106553.1
Product Type	cDAN Clone
Gene Abbr	Alx4
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

ALX4

Background

This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies, cognitive disability, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart. [provided by RefSeq, Oct 2009]

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