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Rat Als2 cDNA Clone(NM_001013413.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR002922

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Gene Information

Cat. No. CDFR002922
Description NativeORF clone of Rattus norvegicus amyotrophic lateral sclerosis 2 (juvenile) homolog (human) (Als2) as transfection-ready DNA NM_001013413.1
Product Type cDAN Clone
Gene Abbr Als2
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene ALS2
Background The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
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