Rat Aloxe3 cDNA Clone(NM_001105793.1)

Name: Rat Aloxe3 cDNA Clone(NM_001105793.1)
SKU: CDFR005525
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR005525

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Product Information

Gene Information

Cat. No.	CDFR005525
Description	NativeORF clone of Rattus norvegicus arachidonate lipoxygenase 3 (Aloxe3) as transfection-ready DNA NM_001105793.1
Product Type	cDAN Clone
Gene Abbr	Aloxe3
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

ALOXE3

Background

This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

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