Rat Aldob ORF Clone(NM_012496.2)

Name: Rat Aldob ORF Clone(NM_012496.2)
SKU: CDCR377405
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR377405

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Product Information

Gene Information

Cat. No.	CDCR377405
Product Type	ORF Clone
Gene Abbr	Aldob
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	1095 bp
Vector	pCMV6-Entry

Target Gene

ALDOB

Background

Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq, Dec 2008]

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