Rat Akr1c3 cDNA Clone(NM_138510.1)

Name: Rat Akr1c3 cDNA Clone(NM_138510.1)
SKU: CDFR013511
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR013511

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Product Information

Gene Information

Cat. No.	CDFR013511
Description	NativeORF clone of Rattus norvegicus aldo-keto reductase family 1, member C18 (Akr1c18) as transfection-ready DNA NM_138510.1
Product Type	cDAN Clone
Gene Abbr	Akr1c3
Species	Rat
Vector	pCMV6Entry

Target Gene

AKR1C3

Background

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

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