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Rat Aipl1 ORF Clone(NM_021590.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR378745

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Product Information

Gene Information

Cat. No. CDCR378745
Product Type ORF Clone
Gene Abbr Aipl1
Species Rat
Tag C-terminal Myc-DDK
ORF Size 987 bp
Vector pCMV6-Entry
Target Gene AIPL1
Background Leber congenital amaurosis (LCA) is the most severe inherited retinopathy with the earliest age of onset and accounts for at least 5% of all inherited retinal diseases. Affected individuals are diagnosed at birth or in the first few months of life with nystagmus, severely impaired vision or blindness and an abnormal or flat electroretinogram. The photoreceptor/pineal-expressed gene, AIPL1, encoding aryl-hydrocarbon interacting protein-like 1, is located within the LCA4 candidate region. The encoded protein contains three tetratricopeptide motifs, consistent with chaperone or nuclear transport activity. Mutations in this gene may cause approximately 20% of recessive LCA. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
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