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Rat Aga cDNA Clone(NM_001031641.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR004177

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Gene Information

Cat. No. CDFR004177
Description NativeORF clone of Rattus norvegicus aspartylglucosaminidase (Aga) as transfection-ready DNA NM_001031641.1
Product Type cDAN Clone
Gene Abbr Aga
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene AGA
Background This gene encodes a member of the N-terminal nucleophile (Ntn) hydrolase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta chains that comprise the mature enzyme. This enzyme is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. Mutations in this gene are associated with the lysosomal storage disease aspartylglycosaminuria that results in progressive neurodegeneration. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is subject to proteolytic processing. [provided by RefSeq, Nov 2015]
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