Rat Acer1 cDNA Clone(NM_001106875.1)

Name: Rat Acer1 cDNA Clone(NM_001106875.1)
SKU: CDFR006602
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR006602

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Product Information

Gene Information

Cat. No.	CDFR006602
Description	NativeORF clone of Rattus norvegicus alkaline ceramidase 1 (Acer1) as transfection-ready DNA NM_001106875.1
Product Type	cDAN Clone
Gene Abbr	Acer1
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

ACER1

Background

Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun et al., 2008 [PubMed 17713573]).[supplied by OMIM, Jul 2010]

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