Rat Ace cDNA Clone(NM_012544.1)

Name: Rat Ace cDNA Clone(NM_012544.1)
SKU: CDFR010364
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR010364

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Product Information

Gene Information

Cat. No.	CDFR010364
Description	NativeORF clone of Rattus norvegicus angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 (Ace) as transfection-ready DNA NM_012544.1
Product Type	cDAN Clone
Gene Abbr	Ace
Species	Rat
Vector	pCMV6Entry

Target Gene

ACE

Background

This gene encodes an enzyme involved in blood pressure regulation and electrolyte balance. It catalyzes the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This angiotensin converting enzyme (ACE) also inactivates the vasodilator protein, bradykinin. Accordingly, the encoded enzyme increases blood pressure and is a drug target of ACE inhibitors, which are often prescribed to reduce blood pressure. This enzyme additionally plays a role in fertility through its ability to cleave and release GPI-anchored membrane proteins in spermatozoa. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme. This polymorphism, as well as mutations in this gene, have been implicated in a wide variety of diseases including cardiovascular pathophysiologies, psoriasis, renal disease, stroke, and Alzheimer's disease. Regulation of the homologous ACE2 gene may be involved in progression of disease caused by several human coronaviruses, including SARS-CoV and SARS-CoV-2. Alternative splicing results in multiple transcript variants encoding both somatic (sACE) and male-specific testicular (tACE) isoforms. [provided by RefSeq, Sep 2020]

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