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Rat Abhd12 ORF Clone(NM_001024314.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR370627

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Gene Information

Cat. No. CDCR370627
Product Type ORF Clone
Gene Abbr Abhd12
Species Rat
Tag C-terminal Myc-DDK
ORF Size 1197 bp
Vector pCMV6-Entry
Target Gene ABHD12
Background This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jan 2011]
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