Rat Abcc8 ORF Clone(NM_013039.2)

Name: Rat Abcc8 ORF Clone(NM_013039.2)
SKU: CDCR377921
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR377921

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Product Information

Gene Information

Cat. No.	CDCR377921
Product Type	ORF Clone
Gene Abbr	Abcc8
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	4749 bp
Vector	pCMV6-Entry

Target Gene

ABCC8

Background

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations in the ABCC8 gene and deficiencies in the encoded protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2020]

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